Principles of Pharmacogenomics: Pharmacokinetic, Pharmacodynamic, and Clinical Implications

YWF Lam - Pharmacogenomics, 2019 - Elsevier
… attributed to innate differences among individuals in their … Despite the scientific advances
made, personalized medicine … could affect the potential for drug interaction with paroxetine, a …

En route to precision medicine through the integration of biological sex into pharmacogenomics

L Gaignebet, G Kararigas - Clinical Science, 2017 - portlandpress.com
… We conclude that the interaction of sex with genetic … assessment of pharmacokinetics
and pharmacodynamics, or the … The biological differences between men and women may …

Sex-related differences in pharmacokinetics and pharmacodynamics of frequently prescribed drugs: a review of the literature

A Farkouh, T Riedl, R Gottardi, M Czejka… - Advances in …, 2020 - Springer
… in men and women [4]. Importantly, there are also significant differences between men and
women in … In contrast, women benefit more from opioids that interact with the κ-receptor, eg …

[HTML][HTML] The pharmacodynamics of antipsychotic drugs in women and men

MV Seeman - Frontiers in psychiatry, 2021 - frontiersin.org
… of differences in pharmacokinetics and pharmacodynamics, clinically relevant adverse drug
reactions differ between men and women (… suggests that the biology of sex and the impact of …

Sex impact on biomarkers, pharmacokinetics and pharmacodynamics

F Franconi, I Campesi - Current medicinal chemistry, 2017 - ingentaconnect.com
… and some hints to pharmacogenomics were evaluated. … In fact, male and female animal
species are biologically differ… by the physiological differences between men and women in body …

Sexual dimorphism in drug metabolism and pharmacokinetics

AM Valodara, KJ SR - Current Drug Metabolism, 2019 - ingentaconnect.com
… The functional differences between the sexes are also … to the interaction of sexgender and
related pharmacogenetics on drug … pharmacodynamics: interaction with biological differences

The role of gender pharmacogenetics in the personalization of drug treatment

E Cecchin, B Posocco, S Mezzalira… - Journal of …, 2023 - ASPET
… on the interaction between gender and pharmacogenetics in … Network for Drug Safety, and
additional scientific consortia are … The most striking difference between males and females is …

[HTML][HTML] Sex differences in pharmacokinetics predict adverse drug reactions in women

I Zucker, BJ Prendergast - Biology of sex differences, 2020 - bsd.biomedcentral.com
scientific community [9]. Regulatory agencies have historically paid insufficient attention to
differences between women and men in … in women and men and considers sex differences in …

Pharmacogenomics: sex differences and application in pediatrics

I Bozic, T Omanovic, L Kuna, T Kizivat… - Southeastern …, 2017 - hrcak.srce.hr
pharmacokinetic differences between men and women are more extensive compared with
variations in pharmacodynamics (… is a rapidly emerging and promising scientific field in which …

Pharmacogenomics: recent progress, sex gender differences, translation into clinical practice, application in pediatrics and future perspectives

M Smolic, I Bozic, T Omanovic, L Kuna… - Southeastern …, 2017 - seemedj.mefos.unios.hr
pharmacokinetic differences between men and women are more extensive compared with
variations in pharmacodynamics (… is a rapidly emerging and promising scientific field in which …